منابع مشابه
Neoplastic meningitis.
cells in the leptomeninges and subarachnoid space. Its incidence seems to be rising because of improvements in the systemic treatment of malignant neoplasms of the hematopoietic system and of other types of cancer. To provide an objective basis for therapeutic decision-making, the authors performed a Medline search of all articles published from January 1975 to December 2005 with the following ...
متن کاملNeoplastic meningitis.
Neoplastic meningitis occurs in approximately 5%-10% of all patients with cancer, and aggressive supportive measures are a critical component of comprehensive care. A literature review of the current diagnostic methods, randomized controlled trials, and available treatments was undertaken; and a comprehensive discussion of best-practice supportive care measures is provided. Although the prognos...
متن کاملTreatment of neoplastic meningitis with intrathecal temozolomide.
Neoplastic meningitis (NM) results from leptomeningeal dissemination of cancers arising within the central nervous system or metastasizing to the leptomeninges from systemic neoplasms. The inability to produce therapeutic drug levels intrathecally (i.t.) with systemic administration and the minimal efficacy of chemotherapeutic agents currently available for direct i.t. use limit therapy. Temozo...
متن کاملIntrathecal Melphalan Therapy of Human Neoplastic Meningitis
We report the activity and toxicity of intrathecal melphalan in the treatment of human neoplastic meningitis in the subarachnoid space of athymic nude rats. Animals received injections via chronic indwelling subarachnoid catheters with 5 x IO5 or 5 x IO6 TE-67I human rhabdomyosarcoma cells or 5 x 10'' D-54 MG human glioma cells and were treated with melphalan on days 8. 5, or 5, respectively. M...
متن کاملPeripheral facial palsy caused by neoplastic meningitis.
OBJECTIVES/HYPOTHESIS To describe the clinical presentation of peripheral facial palsy caused by neoplastic meningitis. STUDY DESIGN Retrospective case series. METHODS Retrospective review, including accompanying symptoms and magnetic resonance imaging (MRI) findings. RESULTS Between January and December 2011, six patients were diagnosed with peripheral facial palsy caused by neoplastic m...
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ژورنال
عنوان ژورنال: Cancer
سال: 2009
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.24210